Novel biological property of pertussis toxin: chemotactic activity on human monocytes.

نویسندگان

  • T Ogawa
  • H Takada
  • S Kotani
  • H Sato
  • Y Sato
چکیده

Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100 degrees C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.

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عنوان ژورنال:
  • Infection and immunity

دوره 41 1  شماره 

صفحات  -

تاریخ انتشار 1983